Today, not only girls but also boys would be at its best. Everyone is trying to look good, healthy and shiny. Fortunately, after some nutrition tips can help keep your skin radiant and beautiful. Different people have different skin types normal, dry and greasy.
The most important of these councils is to take vitamins and the right amount. Vitamin A is important for maintaining skin tissue. Vitamin D is important for the formation of healthy skin. In order to protect the skin from harmful sun rays and other free radicals in the atmosphere, a person needs the help of vitamin E and C.
The easiest way to follow this suggestion and nutrition that is recommended to us because we have a child to eat the right foods. It ?important to follow a balanced diet that is full of vitamins and proteins. This should involve the provision of seasonal vegetables and green on a regular basis, and a lot of fruit. Another important part of our diet and glowing skin is to drink plenty of fluids especially water. It ?important to keep your skin moisturized. Water is used in our body carry all the nutrients. It helps the water, the toxins are eliminated from our body.
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LOS ANGELES ? Exercise relieved symptoms of arthritis in obese mice, even though they lost no weight from their efforts, a study finds.
Excessive weight has long been considered one of the culprits of osteoarthritis, since it puts additional strain on joints. While exercise has been shown in some studies to ease arthritis symptoms, others have found that for overweight and obese people, a fitness regimen can exacerbate the condition.
The study, published online Tuesday in the journal Arthritis & Rheumatism, found that although weight may heighten the risk of osteoarthritis, regular exercise could diminish joint problems by slowing its progression.
Researchers from Duke University worked with 20 8-week-old male mice, half of whom were fed a high-fat diet in which 60 percent of calories came from fat. The other half got their usual food, with 13.5 percent of calories from fat.
As expected, the mice on the high fat diet got pretty chubby; after 12 weeks they had a 55 percent increase in body mass and their body fat percentage rose more than three-fold. Researchers found evidence of osteoarthritis in the mice?s knees, such as markers for inflammation. They also found elevated glucose levels (an indication of prediabetes).
When the obese mice started running regularly on a wheel, changes started happening, despite the fact that they were still on the high-fat diet and losing no weight: the inflammation response was disrupted and glucose tolerance improved.
?I don?t want to say exercise is turning off that inflammatory signal, it just impairs it,? said lead author Timothy Griffin in a news release. ?This shows that if you are obese, it?s better to exercise. Sometimes pain can be a barrier to starting exercise, but if you overcome it, in the long term, it?s better.?
There is a lot to be learned about health and medication, typically it?s straightforward to get overwhelmed. Most individuals I know do probably not take the time to consider the methods they?re caring for their body and the results of their choices on their brief and long term health. I?ve been studying loads about various kinds of various medication and I?ve become convinced that extra people must be informed that there are options to your health and fitness needs.
Basically, alternative medication offers with all kinds of non-traditional medicines and strategies of remedy for the entire medical situations people can discover themselves in. Individuals have begun to be extra involved lately with the issues that they?re putting into their our bodies, so different medicine has turn into considerably of a buzzword that is being thrown round amongst health-acutely aware individuals right now.
I grew to become interested in different medication once I needed to research and write in regards to the latest trends in it for an article in my magazine. I had fairly honestly by no means given much thought to the doctor?s orders for sure medicines and methods of remedy until I started researching for this piece. I quickly realized how cautious we needs to be about anything that we put into our bodies. In any case, we only get one physique to reside in and maintain, so it?s solely our responsibility to be knowledgable about ourselves and to make the absolute best decisions for our own health.
I feel this possession issue is the thing I recognize most about people who find themselves taken with alternative medicine. They are principally proactive people who are on the lookout for new ways to deal with their signs and who are convinced that the extra natural something is, the higher it is for them and for their health.
There?s far an excessive amount of to say about different drugs right here, so my easy objective is simply to inform you that you?re responsible for your health. You?re responsible for all the foods you eat, the drinks you drink, and the medicines and coverings that you choose. So select wisely. Take time to think about your whole choices, and see if various medication might provide a greater resolution for you and your well being needs.
You?ll be able to easily be taught extra by doing an internet search or by grabbing some books on various medicine. There?s a ton of information on the market, so just begin at this time to sift via the assets and find information that is useful for you.
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WASHINGTON (Reuters) ? The United States is close to deciding on whether to label the Pakistan-based Haqqani network as a foreign terrorist group, Secretary of State Hillary Clinton said on Wednesday amid calls for a tougher stance on militants accused of series of high-profile attacks.
"We are in the final, formal review that has to be undertaken to make a government-wide decision to designate the network as a foreign terrorist organization," Clinton told reporters in an appearance with Egypt's visiting foreign minister.
Clinton, noting that the United States had already placed a number of individual leaders of the Haqqani network on its terrorism blacklist, said the United States would work with Pakistan to put pressure on such groups.
"We're going to continue to struggle against terrorism and in particular against those who have taken up safe havens inside Pakistan, and we're going to continue to work with our Pakistani counterparts to try and root them out," she said.
A move to name the Haqqanis as a terrorist group would bar U.S. citizens from providing support to the group and freeze any assets it might have in the United States -- a symbolic step that might relieve some of the mounting U.S. political pressure to take a harder line with Pakistan.
The Haqqani network has been in the spotlight after U.S. officials accused it of mounting this month's attack on the U.S. embassy in Kabul with the support of Pakistan's powerful military spy agency.
The United States has long pressed its ally Pakistan to pursue the Haqqani network, one of the most lethal Taliban-allied Afghan groups fighting Western forces in Afghanistan.
Pakistan denies it supports the Haqqanis and says its army is too stretched battling its own Taliban insurgency to go after the network, which has an estimated 10,000-15,000 fighters.
The head of the Senate Intelligence Committee, Democratic Senator Dianne Feinstein, last week urged Clinton to put the Haqqani network on the terrorism blacklist, saying there was no question it met the standard for inclusion.
Some analysts have speculated that the State Department has not yet taken that formal step in hopes the Haqqanis could be reconciled as part of Afghan peace talks between the government and insurgents. Any such talks now seem unlikely at best.
The Haqqani network, based in Pakistan's North Waziristan tribal area, is named after aging leader Jalaluddin Haqqani. The elder Haqqani was among the mujahideen leaders that fought Soviet troops in Afghanistan in the 1980s, and his group received CIA backing then.
Clinton noted she raised the issue in a 3-1/2 hour meeting last week with Pakistan's foreign minister, underscoring that the Haqqanis represented a threat not only to U.S. interests but also to Pakistan and Afghanistan.
"The United States and Pakistan have vital strategic interests that converge in the fight against terrorism," Clinton said, noting what she said were "tangible results" of cooperation on anti-terrorism including Pakistan's recent capture of a senior al Qaeda operative.
"I have no argument with anyone who says this is a very difficult and complex relationship, because it is," Clinton said. "But I also believe strongly that we have to work together despite those difficulties."
Weddings are a period of time for starting unique relationships, sharing ideas and feelings, experiencing and celebrating. In the list of wedding speeches the daddy of the bride's is constantly special. Since he will be the formal host for those event in the majority of weddings, it is his or her part to delightful everyone and thank the who helped make all the arrangements.
Most fathers have a very unique relationship using their daughters. They recognise that some day, their daughter will become older, fall in adore with someone, get married and go away. And when the morning finally arrives, he will never know what to share! It is troublesome to capture the particular emotions and sentiments of the whole relationship in just a few words and content.
But as any host, it is also important to express everything; not more or less your feelings. To help you start by welcoming all the guests with its own welcome to typically the groom's family. Perhaps you can make some comments about how nice the young ladies look or ways beautifully the flowers are already decorated or the good designs on cherished cake. You could crack a lie or two towards lighten the 'heaviness' for the situation.
Share your thoughts as best in addition to in as straight forward a manner and often. While you are dealing with your daughter, consider her in all the eyes. It means a lot to be able to her. Try in avoiding using cliched words for expressing your emotions. Even a quick 'I love you' for ones daughter are often more than high title of statements.
In some wedding ceremony speeches a father within the bride also mentions how a bride and typically the groom met and once they decided to generate married and just what their plans are going forward. Check in your wife if she wants to thank any particular person and also communicate your regret that some members of your family or friends wasn?t able to attend the marriage ceremony. To conclude, wish everyone a great time at all the festivities and then the dinner to are provided.
Get 20 specialist written Wedding Speeches for ones Father of the particular Bride for quick download. At our big event speech resource site you will see all sorts of information on Funny Wedding Speeches as well as serious stuff very - Come check it out!
Home Page > Home and Family > Parenting > Protect your valuables with an in-floor safe: here?s how
Posted: Sep 26, 2011 |Comments: 0 |
If you want to store valuables at home, a safe is the best protection. Even if you have a good home security system, a safe gives you an extra layer of security. You may be able to replace material items in your home that were lost to theft if you have a homeowner?s insurance policy, but some items can cost you more than money. Important documents are prone to a number of disasters?fire, flood, moisture damage and theft.
To protect your identity and your financial records, you may want to look into installing an in-floor safe. These safes are designed to be permanent parts of your home, so no burglar can remove them. The only way to get in is to know the combination, which provides better security than an unsecured safe. What you don?t want to do is buy a free-standing safe, which the burglars could simply move out of your house to open on their own time.
Benefits of a Floor Safe: Wall safes are generally more popular among people looking to hide their valuables, mostly due to their fairly straightforward installation. But since floor safes are less common, they provide improved protection. Veteran burglars may know where to find even cleverly-hidden wall safes, but they are less likely to check out your floors.
Installing Your In-Floor Safe
Step 1: Choose Your Safe. Make sure you purchase a safe that has a good security rating and is both fire- and flood-resistant.
Step 2: Choose Your Location. Most people install their safes in areas where they can be encased in concrete. Avoid second- or third-floor installation since you may have to reinforce the adjoining ceiling to compensate for the combined weight of the safe AND the concrete. A ground floor is your best choice. Also, since you will be cutting directly into your floor it?s important that you are familiar with the construction of your house and the location of all important wiring and plumbing.
Step 3: Do It Yourself or Hire a Professional? Installing a floor safe is not a simple task. Some companies offer the option of installation with purchase, something to consider if you feel at all unsure about the process.
If you do decide to install it yourself, you will need to gather several items:
A detailed floor plan of your house
A map of all the plumbing in your house, from several angles
A generalized map of the electrical wiring in your house
A map of your house?s support beams
You should be experienced in pouring and mixing concrete. You need several different tools and materials. You should have extensive experience in completing complex home projects. If you feel you can successfully manage the installation yourself, here are the steps to follow:
How to install a floor safe
Procedures differ a bit from manufacturer to manufacturer, but most in-floor safes can be installed in an existing concrete floor by following these steps:
Take the door off the safe, and tape the dust cover over the safe opening.
Draw the shape of the body of the safe on the floor where it?s to be installed, allowing four inches extra width on each side. (If the safe has a square-body, make the drawing square, regardless of the shape of the safe?s door.)
Use an electric jackhammer to break through the concrete to match your markings, using a shovel to make the hole at least three inches deeper than the height of the safe.
Line the hole with plastic sheeting or a weatherproof sealant to help fight moisture buildup in the safe.
Pour enough concrete in the hole to form a stable base for the safe to sit on.
Put the safe in the hole, make sure it is flush and level, and fill in the remaining space with concrete mix. Use a trowel to level the concrete with the floor.
When the concrete is dry, trim away the plastic, and remove any excess concrete.
The Final Step: Hiding Your Safe. Once your in-floor safe is installed, you need to decide the best way to conceal it. If it?s in a carpeted room, you can construct a carpeted trap door for camouflage. You can also place a heavy piece of furniture and an area rug over the safe?s location, but this makes it difficult to access stored items without some time and some heavy lifting. Be creative and use whatever solution works for your house!
Another way to help protect your home from being broken into in the first place is to install a FREE ADT Home alarm system by Gaylord Securities today!
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You are at : Home | Business ? | ? Home Views : 1????Word Count: 870 ?? By : Carolyn Wright
There are home improvement projects that aren't done as often as the more standard ones. There is information available on the most complex projects, and also you are really only limited by your imagination. You know that you can always find a contractor who'll be happy to take your money. But doing it all by yourself, or with the help of some friends, is part of the fun.
Landscaping takes a certain amount of skill which you may have from experience or that you can hire professionally. People who hire the workers tend to be less enamored with working on home improvement. However, if that is something you love, then we wholeheartedly tell you to go for it. Some people will hire a landscaper because of the level of complexity involved with their yard. Reading up on the type of landscaping that you have will help you understand how to take care of it. If you have small trees on your property, you should know how to cut them back so they do not get too large. By planning ahead, you will get into a routine on how to properly care for the flora on your property. It is a daunting experience to paint the exterior of a house. Aluminium and plastic siding is widely used on homes these days. But a great many homes could still use a nice coat of fresh paint. We'll tell you that you need paint that is most suitable for the weather conditions where you live. You do not want to use a paint that will not be able to stand up to the heat if you live where it gets very hot. Additionally, considering the cold weather is a good idea. Therefore you should talk to the people you're buying you paint from to make sure that it's the right stuff.
If you really want an in ground swimming pool, be sure you know what you're doing before you proceed. Pool installation professionals should really be used unless you are skilled at installing one yourself. To be on the safe side, consult other people that have had a pool installed by the company you are thinking about using before you pay them. The worth of your home will definitely rise after your pool has been installed in the ground. Always compare a multitude of perspective companies before deciding on the one to install your in ground swimming pool.
Always remember that safety is first when doing a project, so be prepared and dress appropriately. That is especially true if you are using power tools such as for cutting, etc. And finally, always pay attention to the exterior of your home before you buy any type of plant or bush for landscaping.
Say Goodbye to Legal Insecurities by Hiring a Professional Miami Criminal Lawyer
The act of being arrested and charged with a crime can be very unsettling. It can leave one mentally and emotionally scarred for the rest of his life. But the again not to forget, there can also be penalties for the accused in the form of steep monetary fines, probation and a considerable length of time spent in a county or state jail in case of a conviction in an offence like a felony.
Well, moreover these facts in real time do not seem to sparing the state of Miami either. For everyday there are a burgeoning number of cases where people are being charged and arrested with DUI related (Driving Under Influence) offences. And for most of them hiring the services of a? professional Miami criminal lawyer seems to be the only way out.
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How to select a lawyer?
The search for a good Miami Criminal Lawyer and his subsequent hiring can make a big difference to the eventual outcome of a case and the fate of the accused attached with it. For in real time,? the?? experience of a local Miami criminal lawyer would not only enable the accused to get a better picture of what he is up against but also give him an opportunity to judge what the repercussions of a possible conviction might lead to. His experience gained over the years can be also be the guide for an accused to face any investigation, questioning by the law enforcement agencies and cope with any criminal court processes. In essence, his guidance and counsel will enable the accused to decide what steps and choices will enable him to get a judgement in his favour.
Pros of hiring a local Miami Criminal Lawyer
Hiring of a local Miami criminal lawyer will not only enable the accused to wrest the initiative? but would also put him at a distinct advantage. Since, it is but obvious the lawyer under the circumstances is bound to have a rapport with the judges, prosecutors and the court personnel. Something which can go a long way? towards securing a favourable result for the accused in the case.
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inspection is defined as a sober view of the physical structure and systems of the house, roof to foundation. In simple terms, a home inspected is like giving a physical exam. If problems or symptoms are found, the inspector may recommend further evaluation.As home buyer / seller or real estate professional, you are entitled to know exactly what a typical real estate inspection. The following information should give you a better understanding of exactly what the inspector should (and should not) do for you at home inspection.First main inspection is a visual inspection of these areas accessible to the inspector can clearly see. No destruction or dismantling is done in the opinion, in which the inspector can not tell a client exactly what was clearly focused on the time and date opinion. Inspectors eyes are not better than the buyer, unless the inspector is trained to look for certain tell-tale signs and clues that could lead to the discovery of actual or potential defects or deficiencies.Inspectors base their views on current industry standards available to them of their professional organization. Standards say that the inspector can do, and what the inspector will not do. Many inspectors give a copy of these standards to their customers. If the inspector has not given you a copy, request, or click here and watch at home inspectorsassociation.The industry standards clearly recognize certain areas where the inspector must identify various defects and shortcomings, and identify the specific systems, components and elements which are examined. There are many areas exclusion identifies the standards that the inspector did not realize, for example, private water and sewer systems, solar systems
PERUGIA, Italy ? Italian prosecutors asked an appeals court on Saturday to uphold the conviction of Amanda Knox for the murder of her British roommate and to sentence her to life in prison.
The 24-year-old American sat motionless as Prosecutor Giancarlo Costagliola made his request. The prosecutor also sought the same sentence for Knox's co-defendant, former boyfriend Raffaele Sollecito, at the end of two days of closing arguments by the prosecutors.
A verdict could come as soon as defense teams and a lawyer for the victim's family have their final chance to address the jury.
Both defendants had been convicted by a lower court of the 2007 slaying in the university town of Perugia, central Italy. The lower court had sentenced Knox to 26 years and Sollecito to 25 years for the slaying of Meredith Kercher.
The two deny wrongdoing.
Life imprisonment is Italy's harshest sentence.
Earlier on Saturday, another prosecutor in the trial, Manuela Comodi, defended the forensic evidence that had been used to convict Knox of the murder, firing back at an independent review that criticized the investigation and the work of police in the case.
The defendants appealed the 2007 convictions. Prosecutors in Italy also can appeal, and they did so in the Knox case, using this latest trial to try for the harsher penalty.
Comodi tried to keep the jurors interested in the highly technical discussion about DNA testing and forensic science by using down-to-earth expressions and simple language. At one point, to explain DNA testing, she made references to ingredients used in pasta dishes; at another she pulled out a bra from her bag, seeking to illustrate how she thought the garment was cut from the victim's body.
The DNA is crucial in the case, where no clear motive for the brutal killing has emerged.
Corporate venture capital?s rise to prominence in biotech over the past few years is now a well worn subject. ?It was yet again debated this week at the Windhover PSA meeting, in part triggered by the recent widely-covered launch of the Merck Research Venture Fund. ?Like much in biotech, there are lots of (mis)perceptions about corporate venture capital (CVC) and thought I?d toss in my two cents.
From our vantage point at Atlas, CVC investing has without question been a good thing for early stage life science innovation.? During a period where many of our venture brethren have focused on later stage deals, CVC involvement has brought smart coinvestors to our syndicates, deep pockets of capital, abundant advice & guidance from their R&D organizations, and market ?validation? of downstream Pharma interest.? As evidence of this, we?ve partnered with corporate VCs on most if not all of our recent early stage deals, including Nimbus, Bicycle, Protaffin, F-star, Miragen, and Avila.? Just among those six we?ve syndicated with SROne (4), Novartis (2), Amgen (1), Lilly (1), MerckSerono (1), and Mitsubishi (1).? So its clear we like them.
There are a number of common criticisms of corporate venture worth challenging.
?Here today, Gone tomorrow?:? Critics complain that Pharma changes its venture strategy every few years and so these funds aren?t reliable partners.? Strategies may indeed change, but that criticism holds for all VC firms too: many independent VCs fail to raise their next fund, become zombie funds, or, even worse in an existing syndicate, decide not to support any more early stage deals.? And its worth noting that GSK?s SROne (1985) and J&J?s JJDC (1973) have been around longer as consistent investors than most independent venture firms.? So this worry, often used to disparage CVC, is in general unwarranted.
?Only fair weather friends?: ?A number of critics say that the rise of corporate VC is just a temporary phenom or stop-gap measure in today?s tough environment, and that when the capital markets return they will be once again shunned from the best syndicates.? This strikes me as highly unlikely and feels like using yesterday?s faulty frameworks to opine on the future.? I think a strong presence of corporate VCs is here to stay. Our ecosystem is getting tighter and more connected, and ?open source? models will further support this. In addition, venture is about personal relationships: its not the firm you work with on a deal, it?s the partner.? There are some great partners at these corporate funds that I like to work with and will continue to seek out on new deals: Debbie Harland and Kent Gossett at SR One, Janis Naeve at Amgen, Henry Skinner and Anja Konig at Novartis, Steve Hall at Lilly, and many others.
?Dumb money?: ?This criticism (I think) wasn?t ever a reflection on IQ, but more a perception that CVCs don?t care about price (financial returns) and only ever follow or ?top-up? a round. ?This may have frequently been the case 5+ years ago. ?But the world is different today. While all CVCs have a strategic element to them (as they should), the one?s we know well have explicit financial return expectations just like our funds. ?And they frequently lead or co-lead deals, set the price of rounds they participate in, jump on Boards, and are personally incentivized for making returns. ?One CVC partner just told me they may pass on a deal because it didn?t have 5x return potential at this price. ?I like to hear that market discipline: it helps prevent ?dumb money? pricing that leads to inflation in the market and depresses returns across the board.
So it?s clear that we (all early stage life science VCs) have benefited greatly from the rise of strong corporate venture funds, especially in the scarce capital world of early stage financings. ?And that?s likely to continue.
But the big question is why are corporate venturing efforts good for Pharma?
The two most commonly cited are an improved visibility into emerging biotech and enhanced access to innovation.? I think these two arguments in favor of corporate venturing are frankly very weak and stem from the faulty assumption that CVC is just another form of Business Development.? Its not.
?Biotech Visibility: The reality is that most Big Pharma with any semblance of a Business Development function have plenty of visibility into and awareness of the innovative companies in their disease areas.? This is further cemented through their dedicated venture outreach programs (e.g., ?VC Days?, face-to-face meetings to review a VC firm?s portfolio, etc?), and so I think most Pharma could (and do) have a front row seat on the biotech stage that doesn?t require venture fund activities.
Access to innovative assets.? With regard to using CVC to secure access to new products, there?s little if any evidence that Pharma?s venturing activity leads to the sourcing of new programs or the acquisition of new companies out of their ?portfolio? of investments. I can think of a few examples of deal-making linked to venture activities (e.g., Amgen Ventures? Avidia investment was later bought by Amgen; MerckSerono Ventures invested in F-star and its parent did a BD deal one-year later), but these are anecdotes and don?t reflect any trends in the broader dataset. ?Its pretty clear that in general CVC doesn?t drive products or deals back to the CVC?s parent. ?There may be some evidence, however, that involvement of a corporate VC may signal quality and lead to a favorable bias in returns (StartUp June 2011), but there?s no real evidence for it materially improving a Pharma?s BD activities.
So these outreach and access arguments for corporate venture are at the margin, and probably without much quantitative merit. But I still think Pharma is wise to support some element of corporate venture activity and the reason is simple: it is essential to the health of the early stage ecosystem that the industry relies on for future innovation.
If the sector wants a vibrant environment for building an innovative pool of technologies that could eventually become a part of Pharma?s future pipeline, then we need both the capital and expertise that corporate venture efforts can bring.? Surprising as it may sound, the involvement of a corporate venture partner is often the catalyst for getting an early stage financing round together. ?The other ecosystem benefit is that as Pharma absorbs the challenges facing their own venture efforts, they have and will appreciate the broader challenges to venture investing that we all face.? Hopefully this leads to more win-win thinking.
Unfortunately, having a corporate venture effort is not necessarily a no-brainer investment for any individual Pharma company: if there?s not a specific tangible strategic advantage ?like access or deal flow by having a venture effort, ?then why bother making the investment?
It?s comes down to a game theory question about the sector.? It would be easy to free-ride and cheery pick out of the ecosystem while not investing in it.? But if every big Pharma bailed out of venturing today there?d be a meltdown in the early stage life science venture arena.? Then we?d really have a gap in venture funding (more so than the perceived gap in place today).
I think Pharma companies that are evaluating or refining their corporate venturing efforts should think about it in two distinct buckets.? Venture fund activities for supporting the ecosystem (that can be strategically aligned with long term priorities), and separate BD-directed efforts around securing specific assets.
On the venture fund side, there are at least two flavors:
Plain vanilla corporate venture funds.? These are the lifeblood of what I describe above.? They tend to be ?arms-length funds?, separated from their parent R&D organizations by (semi-porous) Chinese walls so as to prevent issues of IP contamination and the leaking of confidential information. From my perspective, these are really no different than other venture funds ? and are often run by partners with similar backgrounds to those in independent venture firms (e.g., recovering scientists, R&D folks, former biotech executives).
Strategic Limited Partner relationships.? A number of Pharma?s support early stage innovation by making investments directly into venture capital firms.? Biogen and Amgen have both been LPs in funds I know well.? These arrangements enable a broader exposure to venture without having to build an internal team. ?As an important LP (and a rare one with lots of cash to put to work), a Pharma can also influence the nature of the deals done by the fund, and can shape the macro venture fundraising environment by only investing in funds that will do early stage innovation vs later stage incremental assets. ?Being an LP could also be a great way to leverage some of that corporate balance sheet cash, especially if venture returns to its historically attractive rates of return.
The BD-directed ?venturing? efforts are really quite different than traditional venture, although often have fund-like attributes: the Novartis Option Fund exemplifies this model, as do side-car funds like the?MPM-Novartis/J&J option funds, and even the new Mirror Funds at Lilly. There are lots of experiments around these models right now supported by both buy-side and sell-side drivers. ?On the buy-side, Pharma is trying to secure a portfolio of external bets for its future pipeline. ?And the on the sell-side, many VCs are now open to ?defined liquidity path? deal constructs at the inception of a new investment to help mitigate exit risk.? These can involve put-call structures.? If the drug program hits its milestones, the shareholders can ?put? it to Pharma for $X, or Pharma can ?call? it for $Y (where $X<<$Y). ? If it fails, well, that?s one of the 50% that lose money. ?I think that in order for these types of option-based venture efforts to be successful they need to have (a) direct buy-in from the therapeutic area leadership teams that will be considering the option; (b) a more collaborative team structure where the Pharma can provide ?advice & guidance? to make sure the optioned program or company is matured in a favorable or attractive way.? This engagement clearly means confidentiality and patent contamination issues will need to be embraced. Pooling programs may be one way to solve this. ?I think the lack of perceived ?success? by a number of the current existing option fund deals to generate new programs may be in part due to the lack of buy-in and collaboration at the outset.
My big caution about corporate venture efforts is when Pharma attempts to do both things ? business development and venture capital investing ? with the same fund concepts and organizations. ?Its a challenge. ?And this is where I wonder about Merck?s new effort. ?Is it for BD or venture? ?Is it taking options, or not? ?Maybe I just don?t have the details well understood. ?But as Jeremy Levin of BMS often says, partnering and investing are different and require different mindsets. ?I tend to agree with that. ?But even more critically, the practical goals of each are very different for the corporate sponsor: one supports an ecosystem, and the other a specific pipeline.
Today we will discuss the sexual health of men and power, and find the right supplements, that really what they say they are. Like most of us already know, men generally think about sex all the time it does not matter if they are at work or the supermarket, we are constantly thinking about sex than men. But when we get older and understand more about the noise and bustle of life to begin with, most men that their libido is not what it was, how it was used when he was small and masculinity. Do not worry guys it happens to the best of us and this is not usually something about thoughts or let go sleep, because there are so-called remedies are there in the world TODAY ?Today, there should be no problem right page.
wrong, because how do you really know the product you use will really work for you as it is announced. Personally, I think I just tried everthing that is there now with little or no impact on my waist and my manhood, so what I do now. So here?s the good news, I decided to do a lot of research on the subject, to find out what really works and you have for me as for people. I spent months and hundreds of dollars of my own money and many hours ?to count for much,? to find the best all natural supplements and herbal enhancers that really work for men and the desired results and not end up costing an arm and a leg, and guess what. According to many sites and I thought it was fake certificates, you can believe it, I found a gold mine so to speak, a great website that offers not only the best supplements herbs and activators, but it will not break the bank and I was very happy and so was my wife. She said that I do not have so much energy and stamina in the years and the fact that my penis becomes longer and thicker and they can not keep their hands on me. So I thought if I found the mime gold, it would be selfish for me to keep everything to me, so I decided to share with everyone. For my friends telling me how great it is for them and even told me that he saved their relationship to drop this all you and verify the theses great products that could change the work absolutely and only your life, and perhaps even their relationship just visit the link below and you can thank me later.
ORLANDO, Fla. ? A prosecutor trying a millionaire Florida developer on a charge of fatally shooting his wife used the man's own words against him during closing arguments Thursday at his trial.
Prosecutor Robin Wilkinson played a 911 recording in which developer Bob Ward tells a dispatcher five times "I just shot my wife."
"Bob Ward in his very own words," Wilkinson said. "Do we really think he doesn't know what he is saying when he says the words, `I just shot my wife?'"
Ward is charged with second-degree murder in the death of his wife, Diane, in September 2009. She was killed days before she was to give a deposition in a lawsuit alleging that he blew millions of dollars on big houses and expensive cars while his business failed.
Defense attorneys say Ward's wife was suicidal and he was trying to stop her from killing herself. But Wilkinson discounted that claim during her closing arguments, noting that Ward had different explanations for what happened. It went from "I just shot my wife" to "it's a tragic accident" to "Diane killed herself," she said.
The Wards were under tremendous stress from the bankruptcy of his company and a lawsuit over his business practices. A broken wine glass, a wine stain on the patio and a similar stain on Ward's shirt indicated they had been fighting before Diane Ward died, the prosecutor said.
Wilkinson said that prosecutors weren't required to show a motive or that Ward intended to kill his wife.
Ward's attorneys didn't call him to the stand during the testimony part of the trial. His defense attorneys were expected to make their closing arguments later in the day.
Having travel insurance ?? a very essential, ?t gives complete peace ?f mind wh?l? ??? ?r? ?n traveling away fr?m home. B??????, ?t covers ???r entire trip against unfortunate events ?nd save ??? fr?m h?g? financial loss.
B?t, shopping f?r travel insurance ??n b? daunting task f?r many peoples. W?th ?? many choices, h?w ??? ??n d???d? wh??h ?l?n ?? best suited f?r ???? B?t, comparing a few ?m??rt?nt factors, ??? ??n ?h???? travel insurance easily.
Today, ??? w?ll find out various travel insurance policies available ?n th? market b? leading insurance provider. Visiting t? each providers office ?r m?k?ng phone calls t? g?t details ??n b? lengthy process, b?t ?t?s n?t enough t? h??? a suitable travel insurance.
On th? internet, th?r? ?r? various travel insurance comparison sites available f?r ???r convenience. Y?? ??n compare each policy ?nd g?t th? information ??? need t? ??r?h??? travel insurance. Th?? process ?? very q???k ?nd easy way t? view th? best deals ?f th? market. Such a comparison tools shows ?nl? those plans th?t suits t? ???r needs. On th? basis ?f result, ??? ??n easily find out travel insurance wh??h ?? th? cheapest ?nd best ?n coverage.
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Taking overview ?f travel insurance coverage ?? a very ?m??rt?nt f?r getting th? value ?f ???r money. Y?? ?h??ld consider th? following ?m??rt?nt coverage ?nd th??r limit wh?l? ??? ?r? comparing travel insurance.
- Flight Cancellation ?nd Interruption
- Trip/Cruise cost
- Passport Loss
- Baggage Loss ?r Delay
- Medical Expenses
- Medical Evacuation/Repatriation
- Accidental Death Benefit
Group travel insurance ?l?n ?? always better th?n travel insurance b? ?wn, b?????? ?t?s very cheap. If ???r group ?? consists ?f 10 members ?r more ?nd travelling t? th? same direction, th?n getting a group travel insurance ?? a very finest ?nd effective ?h????.
LOS ANGELES ? A 35-year-old man who drew comparisons to fictional super agent Jason Bourne for his ability to evade police and for the weapons, equipment and mystery that surrounded him has pleaded guilty to several drug-related felonies.
A Los Angeles judge sentenced Brian Alexik, who served as his own attorney, to a suspended seven-year prison term and five years' probation.
Police say Alexik evaded them for six weeks in April 2010 after they appeared at his luxury L.A. apartment to investigate a reported gas odor and found weapons, counterfeiting equipment and a mosaic depicting the CIA seal.
Alexik slipped out the fire escape moments before police arrived and was eventually found at his girlfriend's nearby apartment.
The Los Angeles Times (http://lat.ms/n4yPvJ) reports prosecutors opted not to pursue weapons or counterfeit charges.
Your SUV?s wheels and tires are one essentially the most important components of your vehicle. Because SUVs, such because the Land Rover Vary Rover, are 4WD, it could actually go through any terrain that the planet may offer. And when it does, the tires and wheels of your SUV do not simply clearly assist you to achieve your destination as a result of it is the main tools that makes your automobile move. However, the capabilities of the wheels and tires do not simply end there. These elements also emphasize the general look of your vehicle. Furthermore, the wheels can actually improve your automobiles efficiency simply by effective cleaning. Like another automobile parts like Land Rover Vary Rover elements, SUV wheels can eventually be corrosive and tires may wear out because of certain factors.
Getting your SUV perfectly cleaned on a neighborhood automobile wash is a good idea. Nevertheless, the one downside of it?s the cost that you would be spending in an automobile wash. Why go to an automotive wash for those who might clean your wheels by your self, proper? So listed here are some few guides in efficient cleaning and maintenance of your car?s wheels and tires.
Earlier than we proceed to the cleaning session, first it?s best to know the elements that made your wheels and tires unpleasant. Whenever you use your SUV for an extended journey or even in a brief trip, mud particles assault the surface of your wheels. Different unwanted grime on your wheels and tires include highway tars, mud, and different soil crumbs. Acid rain and winter salt are efficient destroyers that can make your wheels brittle.
Cleaning your wheels and tires is definitely step one in car washing. It is best to first select a sure cleaner for your wheels and tires. There are quite a lot of cleansing brokers out in the market at the moment however it?s best to select the safest and best cleaning agent on your wheels and tires. Some cleaning agent comprises a high level of acidity and might easily damage your wheels. Acid-free cleaners are effective cleaning agents which are generally used by automobile wash shops. The most typical cleaner is the household detergent because you will discover it anywhere in your kitchen, or toilette, of course. Not only that, detergent can also be efficient and is the safest cleaner as a result of it doesn?t comprise any harmful elements that may affect your car. Wheels and tires of SUVs are a lot larger and broader than different vehicles so the cleansing process most certainly will take longer compared to sedans.
Now allow us to start with the cleansing process. First, you need to verify your tires for highway filth and mud. If you happen to found one, then scrape it with any onerous object you will discover in your house, however be careful not to scratch your tires so hard. Dilute your chosen cleaner in a bucket of water after which begin brushing your tires. The grooves of your tires are probably the most prone to mud and highway tars. Brush it effectively. After cleaning your tires, proceed to the wheels. Rinse the comb that you simply had used in your tires and start brushing your wheels in up and down motion. Pretty straightforward, right? You must truly clear your wheels and tires once a month for maintenance.
If you would like additional info about tire reviews, pay a visit to Lyndia Puisamony?s web page instantly.
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Do you fall for unfaithful, critical or manipulative people? Are you drawn to aloof and cold personalities? Do you pursue emotionally unavailable partners? Do you fall for married or otherwise involved people? After proclaiming never again, do you attract the same type of person and repeat the cycle?
If so, you?re not simply unlucky in the quest to find the right relationship partner. According to relationship expert and author Nancy Pina, everyone can enjoy a healthy, loving and satisfying relationship ? after understanding the reasons for past relationship choices. Help is available online as she offers immediate sound, objective advice to those seeking relationship help. Each question is answered personally and promptly. Ms. Pina clearly defines each struggle, the reasons they?ve formed, and encourages self reflection to break the cycle.
?I believe in being a daily blessing to others. Responding to emails personally allows me to share my experience and help those struggling in relationships,? says Nancy.
?Most of my inquiries come from people in long term relationships or marriages,? she says. ?I am privileged to offer sound advice, direction and possible solutions. Many look for clarity to why they attracted certain types of people and experiences. The majority of the emails come from individuals who recreated childhood struggles in their adult intimate relationships. They can?t consciously make the connection between the past and the present. I am there to help them see that link.?
When not dispensing relationship advice, Nancy is busy working on a new relationship advice book. The next in her series of ?The Right Relationship Can Happen? books is geared to teens and young adults. ?I am inspired by the large amount of emails from teens and young adults in very intense relationships. Most are unready emotionally and spiritually, although they believe otherwise. I explain the enormity and responsibility associated with marriage and family.?
To interview Nancy Pina regarding couples counseling, relationship issues or any other relationship related problems, call (713) 840-8121, or email nancy@nancypina.com.
Each product has to be well-known among masses and for that, promotion of that product is necessary. However, in what way will we promote a product or service? This is a huge question with several different answers. Nowadays medium online is arising with some truly exciting marketing advertisement solutions. These solutions guarantee less spend and large revenue. That?s the reason why companies are endorsing a number of services and products through search engine advertising, banner advertising, and E-mail campaigns. Actually, advertising in banners and CPM advertising have become popular and much Internet business marketers are going because it for their product promotion.
Actually, CPM advertising is a very simple method of promoting your service on the World-wide-web. Nowadays, all businesses and companies are trying to create interesting web banners and they?re putting them on websites. People occur these stuffs if these ads are good-looking and crowd pleasing enough. These ads obtain clicks on them due to the fact that with this way, an item gets promotion. Some guidelines have been recommended as a way to create banner ads an affordable and advantageous online ad method. While using experts of industries, a banner ad ought not to be made very flashy when the corporation is only just starting. Instead, first timers must put concentration at the banner ad?s copy because most visitors read it and before clicking on the link. It s also obvious that when these viewable text will never be attractive, interesting and motivating then the banner will not be clicked.
In case that happens, you could possibly lose your online prospects and audience. Users of CPM advertising plan every potential way to get the interests of the people. This is certainly indeed the first step for any business or a company in the method of advertising and you could possibly do it right by creating your own banner title considerably more attractive. You might have services associated with an marketing agency online for that. There are numerous CPM advertisers on the internet who definitely are offering services you would like about advertising. A useful and interesting ad content will likely make your readers to believe that what they could actually expect from your advertisement. Your ad should deliver the expectations of the audience and so ads needs to be placed in platforms where in they will receive the maximum exposure.
Therefore, if higher traffic precisely what you will need, CPM advertising will be the precise preference. Learn different guidelines and tips and begin advertising your banner. With this, you are able to attract audience and endorse your products and services.
If you are interested to know how to CPMAdvertising , check this web-site and enjoy how CPMAdvertising invest money for it.
Pulau Mabul Resort stands out as the great choice for individuals attempting to get an incredible diving encounter, despite the fact that snoozing in a blissful position, from the Celebes Sea. Mabul Island Resort can be described as assortment of bungalows on a coconut plantation, from the south eastern place of Pulau Mabul, in close ?
You have got your business up and running. However, you find that you need more money to expand your operations, take on new clients, meet business debts, keep up with payroll and other expenses, or capture another prime piece of business. So, what will you do? Your first thought is to talk with your banker to apply for a commercial loan. Yes, you could approach your local business loan officer in hopes of trying ? yes, trying ? to get him or her to see the value of your business and to appreciate your ability to repay the loan. However, in today?s business climate, you realize that this is not as straightforward as it may seem on the surface.
Given the most recent economic turn down, in today?s business climate, getting a bank loan is more difficult than it has been in recent memory. So, you know that your chances of scoring a loan is slim, at best. You also realize that your credit rating is not sterling. Therefore, in the slim chance that you are offered a loan, it will come with an interest rate much higher than one you would have received had your credit been healthier.
Additionally, given your current financial situation, you realize that, in the event you are offered a loan, it will undoubtedly be one ?secured? by a portion of your business interests. In effect, the bank will become your silent partner. In fact, the bank may require that you pledge your personal assets, such as your home, personal real estate, etc, as a condition for receiving the loan. All of these possibilities, added together, make for a very unappetizing situation. There may be a better option readily available to you.
That option is called ?alternative business financing?. This type of financing is so called because it is an ?alternative? to normal bank lending. In fact, most forms do not require any banking interaction at all. Some of the more popular form include inventory finance, asset-based lending and export-import trade finance (?which we will discuss in other articles in this series). However, the most widely-used form of alternative business financing is called ?factoring?.
Essentially, factoring involves you, the company owner, using your accounts receivable to acquire an advance from a private, non-banking financial entity. Factoring has proven itself a winner for many small and medium-sized businesses and a major means for business owners foregoing the business loan process.
The process works like this: If you, as a business owner, offer terms (30, 60, 45, 90 days, etc) to your customers, you will receive accounts receivable (essentially, an I.O.U) from those customers. You will keep the receivable until the customer pays. Meanwhile, you will be out of the dollar value of the receivable until your customers pay. This is where factoring come in. With factoring, you can receive an advance of up to 85% of the accounts receivables value. Once the customer pays, you will get the remainder of the accounts receivable value, minus the factor?s small financing fee (?normally, 1-3% per each 30-day period). This is not a loan, but an advance.
With this advance, you will have ready access to your own cash to expand your business, take on new clients, pay business debts, keep up with payroll, meet other expenses, capture additional prime pieces of business, etc. Factoring has been used extensively by business persons to avoid the hassle and complications of getting expensive, commercial business loans.
With factoring, there is no need to pledge any type of personal or business assets; (because it is not a loan)no money need be paid back ; factoring fees are normally reasonable; the factoring process is rather simple; and there is no possibility of taking on a silent partner.
Before you attempt to get a commercial business loan, investigate the possibility of alternative business financing. Look closely at factoring as a possible way of avoiding the need for a commercial loan.
Author Resource:- Mike Evans is a an expert in financial cash flow notes and writes extensively on the subject. For more information on factoring, visit http://www.learn-about-cash-flow.com/accounts-receivable-factoring.html. To learn more about other forms of alternative business financing and other cash notes, visit http://www.learn-about-cash-flow.com.
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By: Mike Evans
You have got your business up and running. However, you find that you need more money to expand your operations, take on new clients, meet business debts, keep up with payroll and other expenses, or capture another prime piece of business. So, what will you do? Your first thought is to talk with your banker to apply for a commercial loan. Yes, you could approach your local business loan officer in hopes of trying ? yes, trying ? to get him or her to see the value of your business and to appreciate your ability to repay the loan. However, in today?s business climate, you realize that this is not as straightforward as it may seem on the surface.
Given the most recent economic turn down, in today?s business climate, getting a bank loan is more difficult than it has been in recent memory. So, you know that your chances of scoring a loan is slim, at best. You also realize that your credit rating is not sterling. Therefore, in the slim chance that you are offered a loan, it will come with an interest rate much higher than one you would have received had your credit been healthier.
Additionally, given your current financial situation, you realize that, in the event you are offered a loan, it will undoubtedly be one ?secured? by a portion of your business interests. In effect, the bank will become your silent partner. In fact, the bank may require that you pledge your personal assets, such as your home, personal real estate, etc, as a condition for receiving the loan. All of these possibilities, added together, make for a very unappetizing situation. There may be a better option readily available to you.
That option is called ?alternative business financing?. This type of financing is so called because it is an ?alternative? to normal bank lending. In fact, most forms do not require any banking interaction at all. Some of the more popular form include inventory finance, asset-based lending and export-import trade finance (?which we will discuss in other articles in this series). However, the most widely-used form of alternative business financing is called ?factoring?.
Essentially, factoring involves you, the company owner, using your accounts receivable to acquire an advance from a private, non-banking financial entity. Factoring has proven itself a winner for many small and medium-sized businesses and a major means for business owners foregoing the business loan process.
The process works like this: If you, as a business owner, offer terms (30, 60, 45, 90 days, etc) to your customers, you will receive accounts receivable (essentially, an I.O.U) from those customers. You will keep the receivable until the customer pays. Meanwhile, you will be out of the dollar value of the receivable until your customers pay. This is where factoring come in. With factoring, you can receive an advance of up to 85% of the accounts receivables value. Once the customer pays, you will get the remainder of the accounts receivable value, minus the factor?s small financing fee (?normally, 1-3% per each 30-day period). This is not a loan, but an advance.
With this advance, you will have ready access to your own cash to expand your business, take on new clients, pay business debts, keep up with payroll, meet other expenses, capture additional prime pieces of business, etc. Factoring has been used extensively by business persons to avoid the hassle and complications of getting expensive, commercial business loans.
With factoring, there is no need to pledge any type of personal or business assets; (because it is not a loan)no money need be paid back ; factoring fees are normally reasonable; the factoring process is rather simple; and there is no possibility of taking on a silent partner.
Before you attempt to get a commercial business loan, investigate the possibility of alternative business financing. Look closely at factoring as a possible way of avoiding the need for a commercial loan.
Author Resource:->??Mike Evans is a an expert in financial cash flow notes and writes extensively on the subject. For more information on factoring, visit http://www.learn-about-cash-flow.com/accounts-receivable-factoring.html. To learn more about other forms of alternative business financing and other cash notes, visit http://www.learn-about-cash-flow.com.
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