Razer Blade

The Blade is Razer's first crack at the laptop gaming market, and it looks stunning. Its dark aluminum chassis has only the glowing Razer logo adorning the lid, a clear indication that the company has taken its cues from Apple and Voodoo. The interior specs sound just as lovely: A discrete Nvidia GPU and Intel Core i7 CPU. Unfortunately, as of this post, there's only one configuration available?no customizing. The Razer Blade all sounds well and good, but when its Q4 2011 release date finally hits, gamers are going to have to ask themselves if the whole package is worth the $2,799.99 price tag.

The Blade's 17-inch screen display outputs true 1080p HD. For its size, the chassis is relatively light, weighing only 6.9 pounds compared to other 17-inch gaming laptops like the Alienware M17x that weighs in at 9.8 pounds. The Razer Blade is also extremely thin, measuring about .88 inches thick. Part of the reason for its slim form factor is Razer dropped the optical drive, a smart move as most gamers nowadays get their fix from digital retailers like Steam.

The Razer Blade's true popping feature, however, is its user interface. The full-size chiclet keyboard swaps out the usual numeric keypad for 10 dynamic adaptive tactile keys, which gives you easy-access to hot-key commands. There's also an LCD pad underneath it that displays in-game information when you're using an external mouse or switches to a multi-touchpad for navigating.

Inside the chassis, the Razer Blade features a 2.8GHz Intel Core i7-2640M processor, 8GB of DDR3 RAM, and an Nvidia GeForce GT 555M (2GB) discrete graphics chip with Optimus technology, which will help extend that 60Wh battery's life span. There's 320GB (7,200rpm) of hard drive space, a bit on the small size. It comes with 802.11b/g/n Wi-Fi and Bluetooth 3.0 (for connecting wireless peripherals), Ethernet jack, a USB 3.0 port, two USB 2.0 ports, and 3.5mm headphone and mic combo jack.

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Panel names sites of official presidential debates (The Arizona Republic)

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The Bay Citizen: Oakland Protests Test Mayor Quan?s Activist Background

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Source: www.nytimes.com --- Saturday, October 29, 2011
At another time, Mayor Jean Quan might have joined the protesters. Instead, she is a focus of their wrath. ...

Source: http://feeds.nytimes.com/click.phdo?i=bdf6137a11251f28651cdd7347e5b772

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Diversity by Design

The recent Nature paper from Jef Boeke?s group, ?Synthetic chromosome arms function in yeast and generate phenotypic diversity by design,? begins with an appropriately futuristic sentence: ?The first phase of any genome engineering project is design.? While there have been efforts to redesign viral genomes and chemically synthesize bacterial genomes, whole genomes of living cells are not yet something that can readily be designed from scratch. This new paper (excellently reviewed by Lab Rat a while back) approaches the design of genomes in a fascinating way; instead of trying to decide in advance what a good engineered/engineerable genome looks like or simply copying an existing genome, they designed the sequence of one arm of a yeast chromosome (about 90,000 base pairs) with built-in genetic flexibility, enabling future experiments and future evolution.

While the paper?s abstract states that ?The ability to synthesize large segments of DNA allows the engineering of pathways and genomes according to arbitrary sets of design principles,? the principles they chose are hardly arbitrary. First, the synthetic chromosome arm must work in a living yeast without hurting the cell, and second, the new design should be free of any sequences that could make the strand unstable, which both seem reasonable enough. Third and most importantly, the genome should incorporate diversity by design. This design principle includes three useful and interesting sub-strategies:

1. replacing all the TAG stop codons with TAA stop codons, to allow for coding a new amino acid
2. including ?tag? sequences that allow the researchers to track the parts of their synthetic sequence easily without sequencing the whole chromosome and
3. adding sequences that can SCRaMbLE the genome.

SCRaMbLE stands for synthetic chromosome rearrangement and modification by loxP-mediated evolution, and is a method for large chunks of the genome to flip and recombine with each other, rapidly generating large sequence diversity. The sequence is therefore not fixed but designed to change, to mutate, to recombine, to evolve. Activating SCRaMbLE created many mutations that made the cell less able to grow in certain conditions, perhaps violating the first design principle but at the same time opening up interesting roads to study the genetics, genome structure, and evolution of yeast.

Activating evolution in the lab can be used to refine an important trait, like making enzymes more stable or making yeast that can tolerate higher concentrations of ethanol in brewing, or even create new behaviors through a combination of synthetic biology and directed evolution. George Church, a pioneer in genome engineering writes in a great essay in The Scientist that ?Lab evolution and synthetic biology are about embracing the outliers and creating the occasional hopeful monster, just as evolution has done for millions of years.?

These outliers don?t come from nowhere, they emerge in evolution through chance mutations in the genome or recombination of chunks of DNA like a natural SCRaMbLE. These changes in the existing DNA allow evolution to explore what origin of life researcher Stuart Kauffman calls ?the adjacent possible.? Steven Johnson, author of Where Good Ideas Come From: A Natural History of Innovation, writes in an excerpt in the WSJ that ?the adjacent possible is a kind of shadow future, hovering on the edges of the present state of things, a map of all the ways in which the present can reinvent itself.? By constantly mutating, recombining, and refining, bumping up into the adjacent possible, evolution has brought us from inorganic molecules floating in water to the diversity and complexity of life that exists today.

The adjacent possible doesn?t apply only to the evolution of gene sequences and cells, but as the title of Johnson?s book suggests, it also applies to the recombination of ideas and the hopeful monsters of design and technology. Designers Anab Jain, Jon Ardern, and Justin Pickard of Superflux use the concept of the adjacent possible to discuss their approach to speculative ?design futurescaping? in Blowup: The Era of Objects: ?Positing an unevenly-distributed futurity, many of the components of our speculations as design futurescapers are already out there, in the wild. We visualise images of genetically-engineered bees, artificial clouds, and network cold-zones, and, as science-fictional novums, they seem plausible because so much of their technological and social underpinnings already exist, in however nascent a form.? Recombining all the weird and wonderful technological and social bits and pieces of our present world (many delightfully curated as Daily Idioms by Deb Chachra), we can better imagine and create a future one.

The very best synthetic biology ideas act by activating the adjacent possible in every sense, innovating by recombining ideas and parts shared openly between researchers but also activating the adjacent possible of evolution and the serendipitous recombination of genes, building diversity, evolution, and change into the very DNA of a design.

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Obama Looks Forward to the Return of ?Speaker Pelosi? in 2013 (Michellemalkin)

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Netflix now takes up nearly a third of all Internet bandwidth in North America (Digital Trends)

According to Sandvine?s Fall 2011?Global Internet Phenomena Report, Netflix now makes up 32.7 percent of all Internet traffic in North America and has become the most powerful driver of traffic during the evening. This report?analyzes approximately 200 Internet service providers in 80 different countries. Across all countries,?real-time entertainment applications make up 60 percent of peak downstream traffic, an increase from 50 percent in 2010. Hardware in the entertainment traffic category include smartphones, tablets, set-top boxes, game consoles like the Xbox 360 and smart televisions. Entertainment hardware?dominates the laptop and desktop PC category which only makes up about 45 percent of all Internet traffic.

Video makes up over 32 percent of all peak downstream mobile traffic and the largest contributor to that group is YouTube. Web surfing is in second place at a bit over 16 percent of?peak period aggregate traffic and?peer-to-peer file sharing is also in second place for?daily aggregate traffic. Peak network traffic is typically at maximum levels between 8 to 11 p.m. each evening. Other sources that contribute to traffic at peak times includes real-time communication, gaming, secure tunneling and social networking.?

Netflix subscribers are watching real-time entertainment on multiple screens over the same network as well. Data usage rises based on the size of the screen. For instance, people watching on a 55? HDTV are more likely to opt for a higher quality video stream with similar quality on the multi-channel audio stream. The report also raises the possibility that Netflix traffic has peaked as of Fall 2011 due to the recent developments with Netflix?s loss of 800,000 subscribers. Assuming the subscriber base continues to fall over the fourth quarter, Netflix will be forced to rely on supplying streaming content to emerging?foreign?markets to continue the growth of Netflix?s dominance of Internet traffic.?

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This article was originally posted on Digital Trends

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Stocks open lower after Thursday's big rally

Stocks are falling after a strong rally that left the Standard & Poor's 500 index on track for its best month since 1974.

Markets surged Thursday after European leaders unveiled a deal aimed at defusing the Greek debt crisis. They increased the lending power of a regional bailout fund. Banks agreed to forgive half of Greece's debt.

The Dow Jones industrial average is down 2 points at 12,205 shortly after the opening bell. The S&P 500 is down 4, or 0.4 percent, at 1,279. The Nasdaq composite index is down 9, or 0.3 percent, at 2,729.

Appliance maker Whirlpool Corp. fell 12 percent, the most in the S&P 500, after the company said it will cut 5,000 jobs, citing weak demand and higher costs for materials.

Checking in on how investors are trading ahead of the weekend, with Jeff Kilburg, Treasury Curve senior development director.

Source: http://bottomline.msnbc.msn.com/_news/2011/10/28/8521147-stocks-open-lower-after-thursdays-big-rally

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